Endocrine Abstracts

Introduction: The diagnosis of primary hyperparathyroidism and hypoparathyroidism is still challenging because of the increasing frequency of non-classical presentations. The calcium-to-phosphorus ratio (Ca/P) (CPR) is an inexpensive biochemical marker that could be useful to diagnose parathyroid disorders.Aim: The aim of this study was to assess the performances of CPR in the diagnosis of primary hyperparathyroidism and hypoparathyroidism.<p class="...

Introduction: Primary hyperparathyroidism is a common endocrine disease. Its association with inflammatory and thrombotic events was rarely reported in the literature. The pathophysiological mechanisms of this association remain uncertain. Herein, we report a case of hypercalcemia secondary to primary hyperparathyroidism revealed by a deep vein thrombosis.Observation: A 65-year-old patient was referred to our department for primary hyperparathyroidism. T...

Introduction: Patients with type 2 diabetes mellitus are considered at least at high cardio-vascular risk. Cardiovascular risk factors must be regularly screened. Hyperhomocysteinemia is considered as an independent risk factor for atherosclerotic disease and coronary disease in some studies. The aim of our study was to confirm the association between hyperhomocysteinemia and atherosclerotic disease in patients with type 2 diabetes.Methods: We performed ...

Introduction: Giant pituitary adenomas are defined as tumors with largest diameter ≥40 mm. They are characterized by high invasiveness causing compression of adjacent structures and hormonal dysfunction. The aim of this study was to determine the clinical and paraclinical features, management, and outcome of giant pituitary adenomas.Methods: This was a single-center retrospective study including patients with giant pituitary adenoma. Clinical and p...

Introduction: Double Pituitary adenomas with growth hormone (GH) and adrenocorticotropic hormone (ACTH) secretion are very rare. They are responsible for acromegaly with hypercortisolism. Subclinical corticotropic adenomas are exceptional. Herein, we report the case of a patient with double functional pituitary adenomas causing acromegaly and subclinical Cushing’s disease.Observation: A 45-year-old woman was referred to our department for suspected ...

Introduction: Sarcoidosis may affect the central and peripheral nervous systems in 5–16% of patients. In most cases, such involvement occurs within a multi-systemic disease. Neurological involvement is rare but a potentially life-threatening form of sarcoidosis. The endocrine manifestations of neurosarcoidosis include hypothalamic dysfunction, diabetes insipidus, hypopituitarism, and amenorrhea–galactorrhea syndrome. Herein, we report the case of a patient with hypop...

Introduction: Central diabetes insipidus is a rare condition that typically manifests as polyuria-polydipsia syndrome. Polydipsia helps to maintain normal natremia. Herein, we report the case of persistent hypernatremia in a patient admitted for inaugural diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome.Observation : A 53-year-old woman was referred to our department for inaugural diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome...

Introduction: Leydig cell tumor is rare, accounting for 1% of testicular tumors. Klinefelter syndrome is most often associated with extra-gonadal germ cell tumors. Its association with testicular tumors remains less frequent. Herein, we report the case of a Leydig cell tumor of the testis in a patient with Klinefelter syndrome.Observation: A 46-year-old man was referred to our department for hypogonadism. His past medical history included type 2 diabetes...

Liver dysfunction is common in patients with hyperthyroidism. The underlying mechanisms remain unclear. Predictors of liver dysfunction and recovery are controversial. The aim of this study was to assess the prevalence of elevated liver enzymes in patients with uncontrolled hyperthyroidism and to identify its predictive factors.Methods: This is a retrospective study conducted in 131 patients with hyperthyroidism admitted in the endocrinology department o...

Introduction: Primary hypothyroidism is a common condition. Its treatment is simple and consists of daily levothyroxine intake. Cases with refractory hypothyroidism despite high doses of levothyroxine were reported. Herein, we report the case of a patient with refractory hypothyroidism secondary to gastrointestinal malabsorption that was improved by L-thyroxine liquid oral substitution.Observation: A 49-year-old woman was admitted for refractory hypothyr...